個(gè)人簡(jiǎn)介
新藥創(chuàng)制與綠色合成研究所 所長(zhǎng)
醫(yī)藥分子科學(xué)與制劑工程工信部重點(diǎn)實(shí)驗(yàn)室 副主任
招生碩博專業(yè)：化學(xué)工程與技術(shù)/制藥工程/化學(xué)/藥學(xué)
研究興趣：重大疾病的相關(guān)創(chuàng)新藥物研發(fā)
個(gè)人主頁(yè)
https://www.x-mol.com/groups/ljh_bit
研究領(lǐng)域和方向
針對(duì)臨床未滿足的重大疾病需求，如超級(jí)耐藥菌感染、關(guān)節(jié)炎、胰腺炎、敗血癥、抑郁癥、腦部外創(chuàng)傷、老年癡呆癥等，從具有成藥性優(yōu)勢(shì)的天然骨架（如大環(huán)內(nèi)酯、小檗堿、血根堿、紫檀芪、甘草次酸、碳苷黃酮等）出發(fā)，利用現(xiàn)代化學(xué)生物學(xué)、蛋白質(zhì)組學(xué)、結(jié)構(gòu)生物學(xué)以及人工智能計(jì)算機(jī)尋靶等手段尋找新的靶標(biāo)或者作用模式，合成生物學(xué)或有機(jī)化學(xué)合成新分子，突破現(xiàn)有的治療手段的局限性。通過(guò)迭代藥物設(shè)計(jì)和改造結(jié)構(gòu)，提高提高先導(dǎo)化合物的生物活性和類藥性，同時(shí)，在化學(xué)和生物學(xué)的交叉層面中闡明分子作用機(jī)制，最終獲得針對(duì)重大疾病模型的具有體外、體內(nèi)活性的臨床候選化合物。
教育背景
1999.9~2004.3 北京理工大學(xué)材料科學(xué)與工程學(xué)院，博士（國(guó)防科工委優(yōu)秀畢業(yè)生）
1995.9~1999.7 北京理工大學(xué)化工與材料學(xué)院，學(xué)士（北京市優(yōu)秀畢業(yè)生）
工作履歷
2004.4~至今 北京理工大學(xué)生命學(xué)院/化學(xué)與化工學(xué)院 講師/副教授/教授
2019.7~2020.8 College of Pharmacy, University of Minnesota, Visiting Professor
2010.4~2011.4 College of Pharmacy, Purdue University, Visiting Professor
研究成果
在藥物化學(xué)、化學(xué)生物學(xué)、有機(jī)化學(xué)、計(jì)算機(jī)藥物設(shè)計(jì)方向發(fā)表研究論文，包括Nature Chemical Biology, Cell Discovery, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic Chemistry, Current Medicinal Chemistry, Current Topics in Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters、Journal of Antibiotics等。論文清單見 ORCID: https://orcid.org/0000-0003-1309-8521
代表性論文：
1.Liu Xing-Zhou#, Du Xiao-Yu#, Xie Wei-Song#, Ding Jing#, Zhu Min-Zhen, Feng Zi-Qiang, Wang Hao, Feng Yue*, Yu Ming-Jia*, Liu Si-Meng, Liu Wen-Tian, Zhu Xin-Hong*, Liang Jian-Hua*. Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy. Journal of Medicinal Chemistry, 2024, 67(24): 22168?22190, DOI: 10.1021/acs.jmedchem.4c02202
2.Liu Qian #, Wang Yi-Xin #, Ge Zi-Hao #, Zhu Min-Zhen #, Ding Jing, Wang Hao, Liu Si-Meng, Liu Rui-Chen, Li Chun, Yu Ming-Jia, Feng Yue *, Zhu Xin-Hong *, Liang Jian-Hua *. Discovery of glycosidated glycyrrhetinic acid derivatives: natural product-based soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 280: 116937, DOI: 10.1016/j.ejmech.2024.116937
3.Ding Jing, Zhu Min-Zhen, Liu Si-Meng, Liu Rui-Chen, Xu Shuo, Shehzadi Kiran, Ma Hong-Le, Yu Ming-Jia*, Zhu Xin-Hong*, Liang Jian-Hua*. Discovery of Orally Active Phenylquinoline-based Soluble Epoxide Hydrolase Inhibitors with Anti-inflammatory and Analgesic Activity. Journal of Medicinal Chemistry, 2024, 67(20):18412-18447, DOI：10.1021/acs.jmedchem.4c01766
4.Zhang Na #, Liu Wen-Tian #, Cui Xin-Yi, Liu Si-Meng, Ma Cong-Xuan, Liang Jian-Hua *. Design and Structure-Activity Relationships of Ether-linked Alkylides: Hybrids of 3-O-Descladinosyl Macrolides and Quinolone Motifs. Bioorganic Chemistry. 2024, 151，107712. DOI: 10.1016/j.bioorg.2024.107712
5.Aleksandrova Elena V. #, Ma Cong-Xuan #, Klepacki Dorota #, Alizadeh Faezeh, Vázquez-Laslop Nora, Liang Jian-Hua *, Polikanov Yury S. *, Mankin Alexander S. *. Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nature Chemical Biology, 2024, 20; 1680–1690. DOI: 10.1038/s41589-024-01685-3 (News & Views: Mohamed I. Barmada & Graeme L. Conn. Evading resistance at the double. Nature Chemical Biology, 2024, 20; 1555–1556)
6.Ma Cong-Xuan #, Li Ye #, Liu Wen-Tian, Li Yun, Zhao Fei, Lian Xiao-Tian, Ding Jing, Liu Si-Meng, Liu Xie-Peng, Fan Bing-Zhi, Liu Li-Yong, Xue Feng, Li Jian, Zhang Jue-Ru, Xue Zhao, Pei Xiao-Tong, Lin Jin-Zhong *, Liang Jian-Hua * Synthetic macrolides overcoming MLSBK-resistant pathogens. Cell Discovery, 2024, 10. 75. DOI : 10.1038/s41421-024-00702-y
7.Ma Cong-Xuan, Liu Wen-Tian, Li Xue-Meng, Ding Jing, Liu Si-Meng, Xue Feng, Li Yun,* Liang Jian-Hua.* Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH. European Journal of Medicinal Chemistry, 2024, 276, 116630. DOI: 10.1016/j.ejmech.2024.116630
8.Feng Zi-Qiang, # Ding Jing, # Zhu Min-Zhen, # Xie Wei-Song, Liu Rui-Chen, Liu Si-Si, Liu Si-Meng, Yu Ming-Jia, * Zhu Xin-Hong * Liang Jian-Hua *. Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 266, 116113. DOI：10.1016/j.ejmech.2023.116113
9.Zhang Heao, Xiang Lin, Yang Liang, Wu Si, Liu Sisi, Zhao Juan, Song Da, Ma Congxuan, Ni Junjun, Quan Zhenzhen, Liang Jianhua*, Qing Hong*. WS6 induces adult hippocampal neurogenesis in correlation to its antidepressant effect on the alleviation of depressive-like behaviors of rats. Neuroscience, 2021, 473, 119-129
10.Liang Jian-Hua*#, Yang Liang#, Wu Si#, Liu Si-Si, Cushman Mark, Tian Jing, Li Nuo-Min, Yang Qing-Hu, Zhang He-Ao, Qiu Yun-Jie, Xiang Lin, Ma Cong-Xuan, Li Xue-Meng, Qing Hong*. Discovery of Efficient Stimulators for Adult Hippocampal Neurogenesis Based on Scaffolds in Dragon's Blood. European Journal of Medicinal Chemistry, 2017, 136, 382-392. （DOI：10.1016/j.ejmech.2017.05.025）