個(gè)人簡(jiǎn)介
學(xué)術(shù)兼職
中國(guó)微生物學(xué)會(huì)分子微生物學(xué)及生物工程專業(yè)委員會(huì)委員、中國(guó)化工學(xué)會(huì)生物化工青年工作委員會(huì)委員
Synthetic and Systems Biotechnology期刊編委
《生物工程學(xué)報(bào)》期刊編委
《合成生物學(xué)》期刊編委
榮譽(yù)獎(jiǎng)勵(lì)
第五屆中國(guó)科協(xié)“青年人才托舉工程”
第五屆“閔恩澤能源化工獎(jiǎng)”青年進(jìn)步獎(jiǎng)
研究領(lǐng)域和方向
以天然產(chǎn)物、生物材料等化合物的微生物合成為研究目標(biāo)，變革傳統(tǒng)生產(chǎn)模式，利用代謝工程、合成生物學(xué)、酶工程等手段，構(gòu)建微生物細(xì)胞工廠，解決生物合成的關(guān)鍵科學(xué)問(wèn)題，提高生產(chǎn)效率，旨在實(shí)現(xiàn)上述高附加值產(chǎn)品的綠色生物制造，推動(dòng)工業(yè)化生產(chǎn)。主要研究包括：
1. 解析天然產(chǎn)物在微生物中的合成途徑，實(shí)現(xiàn)新化合物的微生物合成
2. 開發(fā)高效基因組裝和基因組編輯技術(shù)
3. 代謝途徑構(gòu)建與調(diào)控
4. 開發(fā)針對(duì)特定化合物的底盤細(xì)胞改造技術(shù)，構(gòu)建高效微生物細(xì)胞工廠
5. 生物材料的微生物生產(chǎn)
教育背景
2010/09-2015/07：清華大學(xué)，生命科學(xué)學(xué)院，理學(xué)博士
2006/09-2010/06：山東大學(xué)，生命科學(xué)學(xué)院，理學(xué)學(xué)士
工作履歷
2024/01 - 至今：北京理工大學(xué)，化學(xué)與化工學(xué)院，長(zhǎng)聘副教授/特別研究員
2018/05-2023/12： 北京理工大學(xué)，化學(xué)與化工學(xué)院，預(yù)聘副教授/特別研究員
2016/10-2017/11：美國(guó)麻省理工學(xué)院，化學(xué)工程系，博士后
2015/07-2018/04：北京理工大學(xué)，化學(xué)工程與技術(shù)，師資博士后
研究成果
主持國(guó)家自然科學(xué)基金等國(guó)家級(jí)項(xiàng)目4項(xiàng)、國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題2項(xiàng)；參與國(guó)家自然科學(xué)基金項(xiàng)目、973項(xiàng)目等4項(xiàng)。迄今在Metabolic Engineering, ACS Catalysis, Trends in Biotechnology, Biotechnology Advances等國(guó)內(nèi)外本領(lǐng)域高水平期刊發(fā)表學(xué)術(shù)論文30余篇，獲授權(quán)發(fā)明專利 5項(xiàng)。參編出版《合成生物學(xué)》教材，參與出版學(xué)術(shù)專著4部。
主要科研項(xiàng)目
1. 大腸桿菌耐受單萜的動(dòng)態(tài)調(diào)控系統(tǒng)建立及產(chǎn)物合成強(qiáng)化，國(guó)家自然科學(xué)基金面上項(xiàng)目，主持
2. 酵母合成三萜化合物關(guān)鍵酶的量效關(guān)系與協(xié)同調(diào)控，國(guó)家自然科學(xué)基金面上項(xiàng)目，主持
3. 合成植物天然產(chǎn)物的微生物細(xì)胞工廠構(gòu)建及應(yīng)用示范，國(guó)家重點(diǎn)研發(fā)計(jì)劃，子課題負(fù)責(zé)人
4. 新天然與人工產(chǎn)物的定向挖掘和高效合成的平臺(tái)技術(shù)，國(guó)家重點(diǎn)研發(fā)計(jì)劃，子課題負(fù)責(zé)人
5. 中國(guó)科協(xié)“青年人才托舉工程”，主持
6. 酵母生產(chǎn)五環(huán)三萜類化合物的胞外轉(zhuǎn)運(yùn)與合成強(qiáng)化，國(guó)家自然科學(xué)基金青年基金，主持
7. 北京理工大學(xué)創(chuàng)新人才專項(xiàng)計(jì)劃項(xiàng)目，主持
代表性論文
1. Yu Yuan, Rasool Aamir, Liu Haoran, Lv Bo, Chang Pengcheng, Song Hao, Wang Ying*, Li Chun*. Engineering Saccharomyces cerevisiae for High Yield Production of α-amyrin via Synergistic Remodeling of α-amyrin Synthase and Expanding the Storage Pool. Metabolic Engineering, 2020, 62: 72-83 (IF=8.8)
2. Tan Dan#, Wang Ying#, Tong Yi, Chen Guo-Qiang*. Grand Challenges for Industrializing Polyhydroxyalkanoates (PHAs), Trends in Biotechnology, 2021, 39：953-963 (ESI高被引論文，IF=21.9)
3. Sun Wentao, Xue Haijie, Liu Hu, Lv Bo, Yu Yang*, Wang Ying*, Huang Meilan, Li Chun*. Controlling Chemo- and Regioselectivity of a Plant P450 in Yeast Cell toward Rare Licorice Triterpenoid Biosynthesis, ACS Catalysis, 2020, 10: 4253-4260 (IF=13.7)
4. Zhu Ying, Zhou Chen, Liu Xia, Li Xinying, Shi Caifang, Zhang Yapeng, Wang Ying*, Li Chun*. Aided‐efflux and high production of β‐amyrin realized by β‐cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae, Biotechnology and Bioengineering, 2023, 120: 1147-1158(IF=4.4)
5. Wang Ying, Ling Chen, Chen Yong, Jiang Xiaoran, Chen Guo-Qiang *. Microbial engineering for easy downstream processing. Biotechnology Advances, 2019, 37: 107365 (IF=17.7)
6. Zhang Xu, Lin Yina, Wu Qiong, Wang Ying*, Chen Guo-Qiang*. Synthetic Biology and Genome Editing Tools for Improving PHA Metabolic Engineering, Trends in Biotechnology, 2019, 38: 689-700 (IF=21.9)
7. Li Chenyi#, Gao Xiaopeng#, Peng Xiao, Li Jinlin, Bai Wenxin, Zhong Jiadong, He Mengchao, Xu Ke, Wang Ying*, Li Chun*, Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self responsive base/acid regulation. Microbial Cell Factories, 2020, 19: 202 (IF=6.4)
8. Luo Yan, Jiang Yaozhu, Chen Linhao, Li Chun, Wang Ying*. Applications of protein engineering in the microbial synthesis of plant triterpenoids. Synthetic and Systems Biotechnology, 2023, 8: 20-32 (IF=4.7)
9. Zhu Ying, Zhou Chen, Wang Ying*, Li Chun*, Transporter Engineering for Microbial Manufacturing. Biotechnology Journal, 2020, 15, 1900494 (IF=5.7)
10. Alkhadrawi Adham M., Wang Ying*, Li Chun*. In-silico screening of potential target transporters for glycyrrhetinic acid (GA) via deep learning prediction of drug-target interactions. Biochemical Engineering Journal, 2022, 181:108375 (IF=4.4)
11. Jia Nan#, Li Jingzhi#, Zang Guowei, Yu Yuan, Jin Xiaojv, He Yuna, Feng Meilin, Na Xuemei, Wang Ying*, Li Chun*. Engineering Saccharomyces cerevisiae for high-efficient production of ursolic acid via cofactor engineering and acetyl-CoA optimization. Biochemical Engineering Journal, 2024, 109189. (IF=4.4)
12. Li Jinling#, Wang Shuai#, Miao Yinan, Wan Ya, Li Chun*, Wang Ying*. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of Biotechnology, 2023, 375:1-11（IF=4.1）
13. Wang Ying#, Chung Ahleum#, Chen Guo-Qiang*. Synthesis of medium-chain-length polyhydroxyalkanoate homopolymers, random copolymers, and block copolymers by an engineered strain of Pseudomonas entomophila. Advanced Healthcare Materials, 2017, 6: 1601017 (IF=11.1)
14. Wang Ying, Wu Hong, Jiang Xiaoran, Chen Guo-Qiang*. Engineering Escherichia coli for enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in larger cellular space. Metabolic Engineering, 2014, 25: 183-193 (IF=8.8)
15. Wang Ying#, Li Yan#, Xua Tuan, Shi Zhenyu*, Wu Qiong*. Experimental evidence for growth advantage and metabolic shift stimulated by photophosphorylation of proteorhodopsin expressed in Escherichia coli at anaerobic condition. Biotechnology and Bioengineering, 2015, 112: 947-956 (IF=4.4)