個人簡介
主要從事以多肽為識別元件的親和色譜分離分析基礎(chǔ)與應(yīng)用研究。圍繞蛋白質(zhì)靶向分子探針、高性能分離材料、以及生物膜界面精準(zhǔn)化學(xué)測量等方面開展研究工作，為生理病理過程蛋白靶標(biāo)的檢測、功能解析和化學(xué)干預(yù)提供新工具和新方法。以通訊或第一作者在Angew. Chem. Int. Ed., Adv. Healthcare Mater., Chem. Sci., Anal. Chem.等期刊發(fā)表學(xué)術(shù)論文40余篇。授權(quán)中國發(fā)明專利8項。曾獲中國分析測試協(xié)會科學(xué)技術(shù)獎（排名第二）。入選2015年度中國科學(xué)院青年創(chuàng)新促進(jìn)會會員。2021年獲國家自然科學(xué)基金委優(yōu)秀青年基金項目資助。任中國化學(xué)會色譜專業(yè)委員會委員、北京色譜學(xué)會常務(wù)理事。
研究領(lǐng)域和方向
1. 親和多肽的設(shè)計與定向篩選
2. 基于多肽界面工程化的高性能分離材料
3. 靶向分子開關(guān)和活體化學(xué)測量與干預(yù)
4. 蛋白團(tuán)簇/生物顆粒高選擇性分離分析
教育背景
2004.9-2009.7 中國科學(xué)院化學(xué)研究所，分析化學(xué)，理學(xué)博士
2000.9-2004.6 武漢大學(xué)，化學(xué)，理學(xué)學(xué)士
工作履歷
2025.10-至今 北京理工大學(xué)，教授
2017.2-2018.6 美國Texas A&M University, 訪問學(xué)者
2009.7-2025.10 中國科學(xué)院化學(xué)研究所，助理研究員，副研究員，研究員
研究成果
1.Kun Xu, Han Gao, Yongming Li, Yulong Jin, Rui Zhao*, Yanyan Huang*. Synthetic peptides with genetic-codon-tailored affinity for assembling tetraspanin CD81 at cell interfaces and inhibiting cancer metastasis. Angew. Chem. Int. Ed., 2024, 63, e202400129.
2.Yanyan Huang, Chi Zhan, Yang Yang, Lingna Wang, Huifei Zhong, Yang Yu, Xi-Sha Zhang, Cheng Li, Yulong Jin, Guanxin Zhang, Rui Zhao*, Deqing Zhang*. Tuning proapoptotic activity of a phosphoric-acid-tethered tetraphenylethene by visible-light- triggered isomerization and switchable protein interactions for cancer therapy. Angew. Chem. Int. Ed., 2022, 61, e2022083.
3.Yanyan Huang, Xue You, Lingna Wang, Guanxin Zhang, Shilang Gui, Yulong Jin, Rui Zhao*, Deqing Zhang*. Pyridinium-substituted tetraphenylethylenes functionalized with alkyl chains as autophagy modulators for cancer therapy. Angew. Chem. Int. Ed., 2020, 59, 10042-10051.
4.Xiongwei Tang, Huixia Feng, Yongming Li, Tingting Miao*, Han Gao, Rui Zhao, Yanyan Huang*. Bioinspired peptide sensors with tailorable structure for specific and in-situ tracking of Hg2+ biodistribution in living cells upon acute exposure. Biosens. Bioelectron., 2025, 269, 116940.
5.Han Gao, Zhirong He, Jian Chen, Huixia Feng, Rui Zhao, Yanyan Huang*. Macrocyclic peptide-based dual-sensor platform for linkage-specific visualization of ubiquitin chain assembling in live cells. Anal. Chem., 2025, 97, 2351-2358.
6.Kun Xu, Yanting Hao, Han Gao, Huixia Feng, Jian Chen, Rui Zhao, Yanyan Huang*. Engineering peptide-based molecular baits for targeted fishing and protein profiling of exosomes as a liquid biopsy for gastrointestinal adenocarcinoma. Anal. Chem., 2025, 97, 741-748.
7.Jian Chen, Huixia Feng, Chi Zhan, Han Gao, Rui Zhao, Deqing Zhang, Guanxin Zhang*, Yanyan Huang*. Bioinspired chemosensor with configuration-dependent affinity for localized tracking of labile Zn2+ during neuronal differentiation. Anal. Chem., 2025, 97, 10782–10791.
8.Yuanyuan Zhu, Yanyan Huang*, Tian-Hao Yan, Jialuo Li, Yongming Li, Hannah F. Drake, Huifei Zhong, Yulong Jin, Rui Zhao, Hong-Cai Zhou*. Metal-organic framework-based nanoheater with photo-triggered cascade effects for on-demand suppression of cellular thermoresistance and synergistic cancer therapy. Adv. Healthcare Mater., 2022, 11, 2200004.
9.Yongming Li, Huifei Zhong, Yulong Jin, Bo Guan, Jiling Yue, Rui Zhao, Yanyan Huang*. Metal–organic framework accelerated one-step capture and reduction of palladium to catalytically active nanoparticles. ACS Appl. Mater. Interfaces, 2022, 14, 40408?40417.
10.Huifei Zhong, Chunwang Yuan, Jiayuan He, Yang Yu, Yulong Jin, Yanyan Huang*, Rui Zhao. Engineering peptide-functionalized biomimetic nanointerfaces for synergetic capture of circulating tumor cells in an EpCAM-independent manner. Anal. Chem., 2021, 93, 9778-9787.