個人簡介
研究領(lǐng)域和方向
功能有機(jī)染料的合成
生物熒光成像分析
疾病診斷及治療
教育背景
2011.08-2016.07 中國科學(xué)院大學(xué)，有機(jī)化學(xué)專業(yè)，理學(xué)博士，導(dǎo)師：汪鵬飛 研究員
2007.09-2011.07 北京理工大學(xué)，化學(xué)專業(yè)，理學(xué)學(xué)士
工作履歷
2023.01-至今 北京理工大學(xué)，教授
2023.01-至今 北京理工大學(xué)，教授
2021.09-2022.08 大連理工大學(xué)，訪問學(xué)者，導(dǎo)師：彭孝軍 院士
2020.01-2023.01 山東大學(xué)，教授
2016.11-2019.11 香港科技大學(xué)，博士后，導(dǎo)師：唐本忠 院士
研究成果
1. Jiefei Wang, Mingyue Cao, Lulu Han, Ping Shangguan, Yisheng Liu, Yong Zhong, Chaoyue Chen, Gaoyang Wang, Xiaoyu Chen, Ming Lin, Mengya Lu, Zhengqun Luo, Mu He, Herman H. Y. Sung, Guangle Niu*, Jacky W. Y. Lam, Bingyang Shi*, and Ben Zhong Tang*. Blood?Brain Barrier-Penetrative Fluorescent Anticancer Agents Triggering Paraptosis and Ferroptosis for Glioblastoma Therapy. J. Am. Chem. Soc. 2024, DOI: 10.1021/jacs.4c07785.
2. Lifang Guo, Minggang Tian, Zhiyun Zhang, Qing Lu, Zhiqiang Liu, Guangle Niu*, Xiaoqiang Yu*. Simultaneous Two-Color Visualization of Lipid Droplets and Endoplasmic Reticulum and Their Interplay by Single Fluorescent Probes in Lambda Mode. J. Am. Chem. Soc. 2021, 143, 3169. (Supplementary Cover)
3. Guangle Niu, Xiuli Zheng, Zheng Zhao, Haoke Zhang, Jianguo Wang, Xuewen He, Yuncong Chen, Xiujuan Shi, Chao Ma, Ryan T. K. Kwok, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Kam Sing Wong, Pengfei Wang, Ben Zhong Tang*. Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission and Two-Photon Bioimaging. J. Am. Chem. Soc. 2019, 141, 15111. (Supplementary Cover)
4. Tienan Zang, Yachen Xie, Sa Su, Feiran Liu, Qianqian Chen, Jing Jing, Rubo Zhang*, Guangle Niu*, Xiaoling Zhang*. In Vitro Light-Up Visualization of a Subunit-Specific Enzyme by an AIE Probe via Restriction of Single Molecular Motion. Angew. Chem. Int. Ed. 2020, 59, 10003.
5. Mingyue Cao, Yunting Liu, Caihong Xiang, Guangzhen Zheng, Qingping Xiong, Guangle Niu*. Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets. Coord. Chem. Rev. 2025, 522, 216181.
6. Shixian Cao, Xiaoyuan Tian, Mingyue Cao, Jianguo Wang, Guangle Niu*, Ben Zhong Tang*. Solvatochromic Near-Infrared Aggregation-Induced Emission-Active Acrylonitriles by Acceptor Modulation for Low-Power Stimulated Emission Depletion Nanoscopy. Chem. Mater. 2023, 35, 2472.
7. Guangle Niu, Ruoyao Zhang, John P. C. Kwong, Jacky W. Y. Lam, Congping Chen, Jianguo Wang, Yuncong Chen, Xing Feng, Ryan T. K. Kwok, Herman H.-Y. Sung, Ian D. Williams, Mark R. J. Elsegood, Jianan Qu, Chao Ma, Kam Sing Wong, Xiaoqiang Yu*, Ben Zhong Tang*. Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration. Chem. Mater. 2018, 30, 4778.
8. Guangle Niu, Ruoyao Zhang, Yuan Gu, Jianguo Wang, Chao Ma, Ryan T. K. Kwok, Jacky W. Y. Lam, Herman H.-Y. Sung, Ian D. Williams, Kam Sing Wong, Xiaoqiang Yu, Ben Zhong Tang*. Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration. Biomaterials 2019, 208, 72.
9. Mingyue Cao, Ting Zhu, Mengying Zhao, Fanda Meng, Zhiqiang Liu*, Jianguo Wang, Guangle Niu*, Xiaoqiang Yu. Structure Rigidification Promoted Ultrabright Solvatochromic Fluorescent Probes for Super-Resolution Imaging of Cytosolic and Nuclear Lipid Droplets. Anal. Chem. 2022, 94, 10676. (Supplementary Cover)
10. Cheng-Juan Wu*, Xin-Yu Li, Ting Zhu, Mengying Zhao, Zhuoyue Song, Shijie Li, Guo-Gang Shan, Guangle Niu*. Exploiting the Twisted Intramolecular Charge Transfer Effect to Construct a Wash-Free Solvatochromic Fluorescent Lipid Droplet Probe for Fatty Liver Disease Diagnosis. Anal. Chem. 2022, 94, 3881. (Supplementary Cover)