個(gè)人簡(jiǎn)介
主要從事微流控芯片篩選與高選擇性多肽分子識(shí)別研究。國(guó)家級(jí)青年人才，主持國(guó)家自然科學(xué)基金委面上項(xiàng)目，中央軍委后保部開(kāi)放研究項(xiàng)目，北京市自然科學(xué)基金項(xiàng)目等。以通訊作者在SCI期刊發(fā)表論文40余篇，包括Angew Chem Int Ed、Adv Mater、Chem Sci、ACS Nano、Anal Chem、Lab Chip等。入選北京市優(yōu)秀人才培養(yǎng)青年拔尖人才及中科院青促會(huì)。以第一完成人獲中國(guó)分析測(cè)試協(xié)會(huì)科學(xué)技術(shù)（CAIA獎(jiǎng)）二等獎(jiǎng)。任北京市色譜學(xué)會(huì)理事。擔(dān)任JOAT、Micro-Nano Lett、Exploration期刊青年編委。授權(quán)發(fā)明專利10余項(xiàng)，其中1項(xiàng)已進(jìn)入臨床（體內(nèi)）應(yīng)用。
研究領(lǐng)域和方向
1. 靶向分子識(shí)別與精準(zhǔn)化學(xué)測(cè)量
2. 微流控芯片高內(nèi)涵篩選分析
3. 基于多肽分子探針的納米醫(yī)學(xué)檢測(cè)
4. 生物分子影像與智能可控生物醫(yī)用材料
教育背景
2006.09-2011.07，中國(guó)科學(xué)院化學(xué)研究所，分析化學(xué)，理學(xué)博士；
2002.09-2006.06，北京理工大學(xué)，應(yīng)用化學(xué)，理學(xué)學(xué)士。
工作履歷
2023.8至今，北京理工大學(xué)，教授；
2019.07-2023.07，北京理工大學(xué)，特別研究員
2016.11-2017.12 斯坦福大學(xué)，訪問(wèn)學(xué)者
2011.08-2019.06，國(guó)家納米科學(xué)中心，助理研究員、副研究員
研究成果
1.Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, Weizhi Wang*. Tailored cross-β assemblies establish peptide “Dominos” structures for anchoring undruggable pharmacophores. Angew. Chem. Int. Ed. 2022, 61, e202212527.
2.Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chem. Sci. 2022, 13, 4052.
3.Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘a(chǎn)ll-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Adv. Mater. 2022, e202207330.
4.Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, Weizhi Wang*. A “cell space station” for spatiotemporal molecular manipulation of immune checkpoint. ACS Nano 2022, 16, 16332.
5.Shang Wu, Limin Zhang, Weizhi Wang*. Screened α helix peptide inhibitor toward SARS-CoV 2 by blocking a Prion-like domain in the receptor binding domain. Anal. Chem. 2022, 94, 11464.
6.Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Anal. Chem. 2021, 93, 8035.
7.Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology related detection. Anal. Chem. 2022, 94, 431.
8.Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Anal. Chem. 2020, 92, 5650.
9.Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Anal. Chem. 2019, 91, 7245.
10.Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, Weizhi Wang*. Controlled recognition and corona formation by cascade micellar nanoprobes: for boosting glioma theranostics. Anal. Chem. 2022, 94, 11118.
11.Yuwei Tian, Limin Zhang, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosens. Bioelectron. 2021, 184, 113235.
12.Mengzhen Li, Minxuan Wang, Lingyun Li, Limin Zhang, Bing Ma*, Weizhi Wang*. A composite peptide-supramolecular microneedle system for melanoma immunotherapy. Nano Res. 2022, e3032.
13.Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang*. Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring. Biomaterials 2019, 188, 96.
14.Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Adv. Mater. 2018, 30, 1800106.
15.Weizhi Wang*, Zhiyuan Hu*. Targeting peptide-based probes for molecular imaging and diagnosis. Adv. Mater. 2019, 31, 1804827.